Microglia in Mice and Men

A hot debate has broken out among scientists who study microglia, the glorious cells best known as the soldiers of the brain's immune system. OK, "debate" may be a strong word; it's really just a series of gentlemanly letters published over the last couple of months in a neuroscience journal you've probably never heard of. Still, I think the debate is worth highlighting not only because I'm an unabashed fan of microglia, but because it raises one of the most pressing issues facing medical research: the differences between mice and people.

Microglia straddle the fields of immunology and neuroscience. The cells begin in the yolk ...

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