A group of computer gamers are making habit of outshining scientists at their own game. Most of them have no scientific background, but they have a track record of cracking tough scientific puzzles, including at least one that went unsolved for over a decade. They are the Foldit players, and for their latest trick, they’ve shown that they can not only solve hard problems, but also create problem-solving tools that outperform the best in the business.
Foldit is an online multiplayer game, created by Seth Cooper and Zoran Popovic at the University of Washington. It’s designed to tap the collecting problem-solving skills of thousands of people, by reframing scientific problems in a way that even a complete novice can tackle.
In the game, players work together to decipher the structures of proteins. These molecules are feats of biological origami; they consist of long chains of amino acids that scrunch up into complicated three-dimensional shapes. Scientists need to resolve these shapes to understand how the proteins work, and the usual methods involve bouncing X-rays off purified crystals (which is difficult) or using predictive software (which is imperfect). Cooper and Popovic went down a third route: they got gamers to play their way to a solution.