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Injecting Electronics Into Brain Not as Freaky as it Sounds

No need to wait for the cyborg future—it’s already here. Adding to a growing list of electronics that can be implanted in the body, scientists are working to perfect the ultimate merger of mind and machine: devices fused directly to the brain.

A new type of flexible electronics can be injected through a syringe to unfurl and implant directly into the brains of mice, shows a study published Monday in Nature Nanotechnology. Researchers injected a fine electronic mesh and were able to monitor brain activity in the mice.

“You’re blurring the living and the nonliving,” says Charles Lieber, a nanoscientist at Harvard and co-author of the study. One day, he says, electronics might not only monitor brain activity but also deliver therapeutic treatments for Parkinson’s disease, or even act as a bridge over damaged areas of the brain. Deep brain stimulation is already used for Parkinson’s, but uses relatively large probes, which can cause formation of scar tissue around the probe.

The tiny size (just a couple of millimeters unfurled) of the new devices allow them to be placed precisely in the brain while minimizing damage, a separate team of Korean researchers note in an accompanying article. Ultimately, the goal is to interweave the electronics so finely with brain cells that communication between the two becomes seamless.

And that’s just the latest in the merging of electronics into the human body. While Lieber envisions using the implants in science and medicine—for example, to monitor brain activity and improve deep-brain stimulation treatment for Parkinson’s disease—others are already using non-medical electronic implants to become the first generation of cyborgs. These do-it-yourselfers call themselves biohackers, and they aren’t waiting for clinical trials or FDA approval to launch the cybernetic future.

At the website Dangerous Things, you can buy a kit—complete with syringe, surgical gloves and Band-Aid—to inject a small electronic device into your own body. The kits use a radio-frequency ID tag, or RFID, similar to the chips implanted to identify lost dogs and cats. These can be scanned to communicate with other devices. The site warns that implanting the chips should be done with medical supervision and “is strictly at your own risk.”

X-Ray Amal Graafstra
An X-ray image of Amal Graafstra’s hands shows the two electronic tags he had implanted. Image: Dangerous Things

The website’s charismatic founder, Amal Graafstra, has  RFID implants in each hand, and can use them to unlock doors and phones, log into computers, and start his car by waving a hand.

“One of the holy grails of biohacking is the brain-computer interface,” Graafstra says. He likens brain-wiring efforts so far to eavesdropping on neural activity with a glass to our ears and then shouting back with a bullhorn; electronics simply overwhelm the subtle communication between brain cells. “The ultimate goal, I think, would be a synthetic synapse,” he says, in which nanomaterials would function much like living brain cells, allowing far more nuanced communication between mind and machine.

An article in the Telegraph in October 2014 sums up today’s state of the art in brain-hacking:

“Quietly, almost without anyone really noticing, we have entered the age of the cyborg, or cybernetic organism: a living thing both natural and artificial. Artificial retinas and cochlear implants (which connect directly to the brain through the auditory nerve system) restore sight to the blind and hearing to the deaf. Deep-brain implants, known as “brain pacemakers,” alleviate the symptoms of 30,000 Parkinson’s sufferers worldwide. The Wellcome Trust is now trialling a silicon chip that sits directly on the brains of Alzheimer’s patients, stimulating them and warning of dangerous episodes.”

The goal of a complete merger of biology and technology is exciting to champions of transhumanism, which aims to enhance human intelligence, abilities, and longevity through technology.

But not everyone is thrilled about a future filled with genetic engineering, artificial intelligence, and cyborg technology. Implanting electronics in the brain, more so than in the hands or even the eye, goes directly to one of the biggest fear about cyborgs: a threat to free will. Could someone hijack an implant to control its user’s thoughts or actions? Or to read their minds?

That’s unrealistic, at least with current technology. The kinds of electronics that Lieber and others are working on have inherently limited use—such as delivering a small electric pulse to a particular spot—and would be useful only to people with a serious medical condition.

“Some people think we’re going to implant a microprocessor in people’s heads,” Lieber says, “but that has to interface to something.” And a tiny electronic device attached to one part of the brain simply cannot take over a person’s thoughts. “There’s always going to be someone interested in doing something bad,” he adds, so it’s important to monitor the technology as it becomes more sophisticated.

Graafstra says biohacking has “some maturing to do,” and studies like Lieber’s are a good step in bringing scientific rigor to what has at times been a Wild West.

“I think the biohacker understands that we are our brains,” he says. “You are your mind, and the body is the life support system for the mind. And like an SUV, it’s upgradeable now.”


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Wasps and flies have hidden rainbows in their wings

The wing of a fruit fly, viewed against a white background, looks very ordinary. It is transparent, with no obvious colours except for some small brownish spots. But looks can be deceptive. If you put the wing in front of a black background, it suddenly explodes in a kaleidoscope of colour. Oranges, blues, greens, violets – virtually the entire rainbow dances across the wing, except for red.

A French scientist called Claude Charles Goureau first noticed these vivid hues back in 1843. Since then, they have languished in obscurity, “apparently unnoticed by contemporary biologists”. Whenever new species of wasps or flies are described, their discoverers almost never mention the coloured patterns of the wings. The visible pigments have even been described as “evolution in black and white”. It’s like walking through an art gallery with a blindfold.

Now, Ekaterina Shevtsova from Lund University has taken off the blind. By photographing several species against dark backgrounds, she has revealed a world of hidden colour, rivalling that of more obviously beautiful insects. “The claim that fly and wasp wing patterns are no match for the incredible diversity of colourful butterfly wing patterns is obsolete,” she says.


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Bird of paradise creates colourful dance with microscopic mirrors in its feathers


In a small forest clearing in Papua New Guinea, a male six-wired bird of paradise is getting ready for a show-stopping number. He rears up and spreads his wings so that they encircle his body like a ballerina’s skirt. He begins to dance, bobbing from side to side to side while shaking his head and waggling his six bizarre plumed wires. And all the while, his chest feathers flash with an ever-changing palette of orange, yellow, green and blue. Few animal displays so wonderfully merge the sublime and the ridiculous.

The flashing chest feathers are an eye-catching part of the bird’s routine. Many birds, from peacocks to starlings, have shiny feathers that change colour but those belonging to the six-wired bird of paradise are special. Thanks to their unique shape, each one acts as a three-way mirror, allowing the bird to produce changes of colour that are far more dramatic than what other birds can manage.


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A spider web that spans rivers made from the world’s toughest biological material

This is an arachnophobe’s worst nightmare: the largest spider web in the world. It belongs to the Darwin’s bark spider, which spins its gargantuan trap over entire rivers and lakes. Its shape – a simple ‘orb web’ – is normal enough, but its size is anything but. The main anchor thread that holds the web in place to both riverbanks can be as long as 25 metres and the main sticky core can be as large as 2.8 square metres.

With a web that big, it’s no surprise that Darwin’s bark spider uses the toughest silk of any species. It can resist twice as much force as any other spider silk before rupturing, and over 10 times more than a similarly sized piece of Kevlar. It’s not just the apex of spider silk – it’s the toughest biological material ever found.


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Pocket science – bursting bubbles make more bubbles, and snakes on the wane

Not Exactly Pocket Science is a set of shorter write-ups on new stories with links to more detailed takes by the world’s best journalists and bloggers. It is meant to complement the usual fare of detailed pieces that are typical for this blog.

Bursting bubbles create rings of daughter bubbles

Popping a bubble on a body of water seems like an unspectacular event, but there’s real beauty in what happens if you look at it carefully. For James Bird at Harvard University, that meant filming the exploding bubbles with a high-speed camera. His beautiful videos reveal that contrary to popular belief, a popped bubble doesn’t just vanish. Instead, it gives birth to a ring of smaller daughter bubbles, each of which can produce an even smaller ring when it bursts.

The bubble’s curved nature means that the air inside it is at a higher pressure than air outside it. When a hole forms in the bubble, this pressure difference disappears and the film starts to recedes away. The film experiences an inward force along its surface, but an outward force at its rim – as a result, it folds outwards back onto itself, trapping a donut of air. The donut, however, is unstable and it soon breaks up into several smaller bubbles. The whole process takes place in a few thousandths of a second and it can only happen twice before the daughter bubbles get too small.

This process is surprisingly common. It applies to liquids from water to oil, regardless of their viscosity, and it happens in soapy sinks and foamy oceans alike. Bird also found that the bursting of each daughter bubble released tiny liquid droplets into the atmosphere. These aerosols may be miniscule but they have a few important repercussions. They’ve been implicated in the spread of infectious diseases in swimming pools and hot tubs and they contribute to the cycling of chemicals from the oceans into the atmosphere.

Reference: Nature http://dx.doi.org/10.1038/nature09069

More from Geoff Brumfiel at Nature

Image and video by C.Bird


Snakes on the wane (credit to Sciencepunk for the headline)


A depressing number of important animal groups are facing massive population crashes, including amphibians, corals and most recently lizards. Now snakes are the latest faction to join this pessimistic list. An international team of scientists led by CJ Reading did a survey of 17 snake populations, covering 8 species from the European grass snake to the African gaboon viper. They found that 11 of the populations have declined at an alarming rate since the mid 1990s, while 5 have remained relatively stable. The crashing populations all showed a “tipping point” trend, where their numbers suddenly and steeply fell over four years, after a lengthy period of stability. They’ve all levelled off since but one decade on, their numbers show no sign of recovering.

The trends are worrying especially because we still have no idea what’s behind them. It’s telling that all of the five stable populations lived in protected areas, while the crashing species hailed from regions troubled by human activity. Their fates could be driven by falling habitat quality and a lack of prey. It’s also notable that all but one of the stable five are wide-ranging and active foragers, while the declining species are typically ambush predators that stay in the same restricted range. These “sit-and-wait” hunters are more vulnerable to human activity that disrupts the habitats they need to hide in, and they usually grow and breed slowly.

Whatever the cause, it seems to be universal. Reading’s team found that tropical species like Nigeria’s rhinoceros viper are experiencing similar population crashes as temperate ones like the British smooth snake, and all within the same period of time. To Reading, this suggests that the declines share a common and widespread cause – climate change would be an obvious candidate but that needs to be tested.


Reference: Biology Letters http://dx.doi.org/10.1098/rsbl.2010.0373

More from the Guardian

// Photos by Fafner and Tim Vickers

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Pocket Science – when enslaved bacteria go bad, gut microbes and fat mice, and stretchy beards of iron

The Not Exactly Pocket Science experiment continues after the vast majority of people who commented liked the pilot post. I’m really enjoying this, for quite unexpected reasons. It’s forcing me to flex writing muscles that usually don’t get much of a workout. Writing short pieces means being far more economical with language and detail than usual. It means packing in as much information as possible while still keeping things readable. And it means blitz-reading papers and writing quickly without losing any accuracy.

One quick note before the good stuff: last time, a few people suggested that I put each NEPS item in a separate post, but the majority preferred multiple items per post. For now, I’m keeping it that way because otherwise, the longer pieces would be diluted by the smaller ones. We’ll see how that works for the foreseeable future.

Rising DAMPs – when enslaved bacteria turn our bodies against themselves

Our immune systems provide excellent defence against marauding hordes of bacteria, viruses and parasites, using sentinel proteins to detect the telltale molecules of intruders. But these defences can be our downfall if they recognise our own bodies as enemies.

All of our cells contain small energy-supplying structures called mitochondria. They’re descendents of ancient bacteria that were engulfed and domesticated by our ancestor cells. They’ve come a long way but they still retain enough of a bacterial flavour to confuse our immune system, should they break free of their cellular homes. An injury, for example, can set them free. If cells shatter, fragments of mitochondria are released into the bloodstream including their own DNA and amino acids that are typical of bacteria. Qin Zhang showed that trauma patients have far higher levels of such molecules in their blood than unharmed people. Our white blood cells have sentinel proteins that latch onto these molecules and their presence (incorrectly) says that a bacterial invasion is underway.

This discovery solves a medical mystery. People who suffer from severe injuries sometimes undergo a dramatic and potentially fatal reaction called “systemic inflammatory response syndrome” or SIRS, where inflammation courses through the whole body and organs start shutting down. This looks a lot like sepsis, an equally dramatic response to an infection. However, crushing injuries and burns can cause SIRS without any accompanying infections. Now we know why – SIRS is caused by the freed fragments of former bacteria setting off a false alarm in the body. The technical term for these enemies within is “damage-associated molecular patterns” or DAMPs.

More from Heidi Ledford at Nature News

Reference: Nature DOI:10.1038/nature08780

Different gut bacteria lead to mice to overeat

On Wednesday, I wrote about the hidden legions residing up your bum – bacteria and other microbes, living in their millions and outnumbering your cells by ten to one. These communities wield a big influence over our health, depending on who their members are. Matam Vijay-Kumar found that different species colonise the guts of mice with weakened immune systems, and this shifted membership is linked to metabolic syndrome, a group of obesity-related symptoms that increase the risk of heart disease and type 2 diabetes.

Vijay-Kumar’s mice lacked the vital immune gene TLR5, which defends the gut against infections. Their bowels had 116 species of bacteria that were either far more or less common than usual. They also overate, became fat, developed high blood pressure and became resistant to insulin – classic signs of metabolic syndrome. When Vijay-Kumar transplanted the gut menagerie from the mutant mice to normal ones, whose own bacteria had been massacred with antibiotics, the recipients also developed signs of metabolic syndrome. It was clear evidence that the bacteria were causing the symptoms and not the other way round.

Vijay-Kumar thinks that without the influence of TLR5, the mice don’t know what to make of their unusual gut residents. They react by releasing chemicals that trigger a mild but persistent inflammation. These same signals encourage the mice to eat more, and they make local cells resistant to the effects of insulin. Other aspects of the metabolic syndrome soon follow. The details still need to be confirmed but for now, studies like this show us how foolish it is to regard obesity as a simple matter of failing willpower. It might all come down to overeating and inactivity, but there are many subtle reasons why an individual might eat too much. The microscopic community within our guts are one of them.

Read an amazing take on this from Carl Zimmer at the Loom and a previous post from me

Reference: Science DOI:10.1126/science.1179721

The stretchy iron-clad beards of mussels

For humans, beards are for catching food, looking like a druid, and getting tenure. But other animals have beards with far more practical purposes – mussels literally have beards of iron that they use as anchors. The beard, or byssus, is a collection of 50-100 sticky threads. Each is no thicker than a human hair but they’re so good at fastening the mussels to wave-swept rocks that scientists are using them as the inspiration for glue. So they should. The byssus is a marvel of bioengineering – hard enough to hold the mussel in place, but also stretchy enough so that they can extend without breaking.

The mussel secretes each thread with its foot, first laying down a protein-based core and then covering it in a thick protective layer that’s much harder. When Matthew Harrington looked at the strands under a microscope, he saw that the outer layer is a composite structure of tiny granules amid a looser matrix. The granules consist of iron and a protein called mfp-1, heavily linked to one other – this makes the byssus hard. The matrix is a looser collection of the same material, where mfp-is 1 heavily coiled but easy to straighten – this lets the byssus stretch. The granules have a bit of give to them but at higher strains, they hold firm while the matrix continues extending. If cracks start to form, the granules stop them from spreading.

It’s unclear how the mussel creates such a complicated pattern, but Harrington suggests that it could be deceptively simple – changing a single amino acid in the mfp-1 protein allows it to cross-link more heavily with iron. That’s the difference between the tighter granular bundles, and the looser ones they sit among.

More from Eric Bland at Discovery News and stories of bioengineering from me, including triple-armoured snails, shatter-proof teeth and sharp squid beaks.

Reference: Science DOI:10.1126/science.1181044

Cause of dinosaur extinction revealed confirmed

Sixty-five million years ago, the vast majority of dinosaurs were wiped out. Now, a new paper reveals the true cause of their demise – legions of zombies armed with chaingu… wait… oh. Right. An asteroid. You knew that.

More from Mark Henderson at the Times

Reference: Science DOI:10.1126/science.1177265


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Three-layered shell of deep-sea snail could inspire next-gen body armour

Deep beneath the ocean’s surface lie the “black smokers“, undersea chimneys channelling superheated water from below the Earth’s crust. Completely devoid of sunlight, they are some of the most extreme environments on the planet. Any creature that can survive their highly acidic water, scorching temperatures and crushing pressures still has to contend with assaults from predatory crabs. What better place, then, to look for the next generation of body armour technology?

The scaly-foot gastropod (Crysomalion squamiferum) was discovered just 9 years ago at an Indian black smoker and it may have one of the most effective animal armours so far discovered. Its shell is a composite, made of three layers, each with different properties and made of different minerals. Together, they form a structure that’s completely unlike any known armour, whether natural or man-made. It can protect the animal from the searing heat of its habitat, stop its precious minerals from dissolving away in the acidic water and resist the crushing, penetrating, peeling claw-attacks of predatory crabs.

Animals have been protecting themselves with armour long before humans starting shaping steel and Kevlar. To create a protective covering, human designers must account for a mind-boggling array of physical traits including thickness, geometry, strength, elasticity and more. But evolution can take all of those factors into account without the guiding hand of a designer, putting thousands of structures through the test of natural selection and weeding out the best combinations. The results are the culmination of millions of years of research and development and they are striking in their effectiveness.

Haimin Yao from MIT works in the lab of Catherine Ortiz, a group that has been studying the defences of animals including sea urchins, chitons, a group of marine molluscs, to the Senegal bichir, a type of armoured fish.  

Yao discovered the secrets behind the snail’s shell by slicing through it in cross-sections and studying its structure at a nanometre level. He even attacked it with a diamond-tipped probe, to simulate the crushing attacks of the crabs that frequent the black smokers. Using this data, Yao created a virtual simulation of the shell and put it through a digital crash-test, crab claws and all.


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Tiny built-in cracks stop teeth from shattering

Blogging on Peer-Reviewed ResearchOur teeth are a mystery. The set we grow during late childhood stays with us throughout our lives, biting and chewing thousands of times a day. They can withstand forces of up to 1,000 newtons and yet, the material that coats them – enamel – is little tougher than glass. How does this extraordinarily brittle substance not shatter into pieces every time we crunch a nut or chomp on an apple?

Molar.jpgHerzl Chai from Tel Aviv University found the answer, and it’s a surprising one. At a microscopic level, our teeth defend against fractures by developing with cracks already built in. These pre-made defects are known as “tufts” because of their wavy appearance. They are scattered throughout the enamel and share any physical burdens placed on a tooth, so that no one part has to take the full brunt.

By pressing down on individual teeth using a metal rod, Chai found that it’s relatively easy to create a crack in a tooth, but much harder to actually make it grow bigger to the point where the tooth properly breaks. The tufts, together with structures that prevent cracks from growing, are responsible – they allow us to chew without catastrophe. Our teeth aren’t built to avoid damage, but they’re incredibly good at containing it.

Humans aren’t alone in this – Chai compared out teeth to those of sea otters, and found the same adaptive features under a microscope. It may seem like an odd pairing, but we share a fondness for hard-shelled foods with sea otters – we like nuts and seeds, while they can’t get enough of shellfish. These similarities are reflected in our teeth.


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Carbon nanotubes could behave like asbestos

Blogging on Peer-Reviewed Research
In the late 19th century, asbestos became a building material of choice. Resistant to heat, electricity and corrosion, it found many uses including  home insulation, brake pads and ship-building. By the time that the first health problems were reported, the material was commonplace. In the UK, the material was only restricted in 1983 after thousands of people were exposed during the post-war era. The result is a latent epidemic of related diseases including a rare type of cancer called mesothelioma, which is becoming more common and is only expected to peak in incidence over the next decade or so.

Carbon-nanotubes.jpgThe glacial pace with which governments started to regulate asbestos use has put thousands of lives in jeopardy and it’s a disaster that we could do with not repeating. But while asbestos is yesterday’s construction material, a new substance being heralded as the building material of tomorrow has the potential to cause similar health risks – carbon nanotubes.

A new study suggests that carbon nanotubes can cause asbestos-like damage if they are injected into the bodies of mice. The results are cause for concern but not panic. The study didn’t show that the nanotubes can build up in body cavities of their own accord, nor if this damage would eventually result in the mesotheliomas that asbestos can cause. It does however show that we are running before we can walk if the widespread commercial use of carbon nanotubes goes unregulated without rigorous research on their safety.


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A squid’s beak is a marvel of biological engineering

Blogging on Peer-Reviewed Research
Imagine that you hand is made of jelly and you have to carve a roast using a knife that has no handle. The bare metal blade would rip through your hypothetical hand as easily as it would through the meat. It’s clearly no easy task and yet, squid have to cope with a very similar challenge every time they eat a meal.

Beak.jpgThe bodies of squid, like those of their relatives the cuttlefish and octopus, are mainly soft and pliant, with one major exception. In the centre of their web of tentacles lies a hard, sharp and murderous beak that resembles that of a parrot. The beak is a tool for killing and dismembering prey and the large Humboldt squid (Dosidicus gigas) is known to use its beak to sever the spinal cord of fishy prey, paralysing them for easy dining.

The Humboldt squid’s beak is two inches long and incredibly hard (difficult to dent or scratch), stiff (difficult to bend out of shape) and tough (resistant to fractures). This combination of properties makes the beak harder to deform than virtually all known metals and polymers. That’s all the more remarkable because unlike most animal teeth or jaws, it contains no minerals or metals. It’s made up solely of organic chemicals and manages to be twice as hard and stiff as the most competitive manmade equivalents.

By comparison, the mass of muscle that surrounds and connects to the beak is incredibly soft, the equivalent of a jelly hand gripping a bare metal blade. With such mismatched tissues, how does the squid manage to use its killer mouth without tearing the surrounding muscle to shreds?