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What Makes a Blond Blond? Very Little.

From a biological point of view, your skin and hair color is 1/ 3,200,000,000th of your body’s chemistry. That’s it. We humans may think overmuch about our outsides, but on the inside our DNA is thinking, “Who cares?”

After all, you and I are built from a long chain of chemicals, half from our moms, half from our dads—the famous 3.2 billion As, Ts, Cs, and Gs that make up our DNA. We now think that the difference between being a typical Nigerian with dark skin or a typical Finn with very pale skin comes largely from a change in one pair of letters. That’s one in 3.2 billion pairs. It’s hard to believe a change that small creates such a large effect …

Drawing by Robert Krulwich
Drawing by Robert Krulwich

… but here’s how it seems to work. Skin color depends on the pigment melanin. Melanin is produced by cells called melanocytes. Lots of melanin makes you darker. Less melanin makes you lighter. When David Kingsley, a Stanford professor of developmental biology, and his team looked at the billions of letters that make up our DNA …

A block of text As, Ts, Gs, and Cs, representing DNA

… they found buried in this alphabet soup a bunch of letters that make up a gene called Kitlg (for KIT ligand, a protein-coding gene). For purposes of illustration (and this is totally fanciful) I’m imagining the Kitlg gene as some letters way up near the right corner of our clump of DNA. What does Kitlg do? Well, it’s found in many animals. Fish have it. We have it. It seems to help make blood, sperm, and cells that produce color, especially melanin.

Kitlg

Here comes the surprising part. If you look at Kitlg closely, writes science journalist Kat Arney, it seems to be a “regulatory” gene—it tells other genes what to do. While some genes are construction workers, building blood cells, muscle cells, and liver cells, Kitlg is a foreman. It tells the bone guys, the blood guys, the liver guys, “Stop!” or “Go!” Instead of a builder, Kitlg seems to be a turn-on-er or a turn-off-er and is, writes Arney, “chock-full of control switches.”

So what does Kitlg switch on? Looking more closely, Kingsley found that Kitlg sends a message to a gene that isn’t exactly close by. It’s some 300,000 letters away (so I’m going to fantasize and put this gene—a second clump of letters—on the lower right corner of our map).

How the signal finds it way through this dense soup of letters is not well known, but when the message lands, it affects the gene …

Kitlg activating melanin

… that produces melanin. If the signal strongly says, “Go!”, the melanin will turn fully on and will darken our skin and our hair. If the signal is weaker, if it says, “Go a little,” then the skin and hair will stay lighter, even pale.

Finding the Needle in the Haystack

So why do white Europeans consistently have less melanin than West Africans? Kingsley’s team looked at the As, Gs, Cs, and Ts in the switch in both groups and found a single difference.

An “A” in the Africans had become a “G” in the Europeans. A one-letter change. That’s all. But that difference changed melanin production. The “A” was apparently triggering a full “Go!” command. The “G,” on the other hand, wasn’t quite as effective at activating the gene—its signal produced less melanin.

Photograph by Sarah Leen, National Geographic Creative
Photograph by Sarah Leen, National Geographic Creative

 

After working with skin cells in his lab, Kingsley was persuaded that this one-in-3.2-billion difference was creating much of the variation we see in our multicolored world. It’s true, of course, that humans come in 30 or so different shades (color expert Pantone finds almost a hundred), so, writes Kat Arney:

… the difference in the Kitlg switch only explains part of our skin colour, rather than the whole thing. David suspects that there are probably other similar genes and switches out there that add up to give each person their particular hue. [See more on this below.]

But Kitlg is central. It not only explains skin color, but it also determines hair color. In 2014, Kingsley co-authored a paper about blonds. What, he asked, makes a blond blond?

Once again he found a single control switch in blond Europeans that, again, turned out to be one letter different from typically dark-haired people. And, once again, that single difference made it harder to turn on the melanin, the darkening agent, “enough to significantly cut down the melanin production in hair cells and make them fair.”

The Blond Difference

“Growing up in the 1980s,” writes Arney, “I would often hear jokes about blondes being stupid – and as a brunette (to my shame) I would often repeat them. I now know better, but many people apparently don’t.”

When Elle Woods, played by Reese Witherspoon, shows up at Harvard Law School in Legally Blonde, this happens:

We’re told over and over that hair color matters, that blondes “have more fun,” that gentlemen prefer them, that they’re dumber than the rest of us, that color differences reflect a deeper, more subtle divide. When Kingsley’s study came out in 2014, the popular press went ga-ga with blond jokes, so he decided to turn his science paper into a teaching moment. In a press release he said:

It’s clear that this hair color change is occurring through a regulatory mechanism that operates only in the hair. This isn’t something that also affects other traits, like intelligence or personality. The change that causes blond hair is, literally, only skin deep.

So now we know. Which is a humbling lesson when you consider, writes Arney, that:

Countless numbers have been unfairly judged, oppressed or killed throughout history because of the colour of their skin, yet it boils down to little more than a handful of DNA letters in a few genetic switches. For a species named after our intelligence – Homo sapiens translates as ‘man who knows’ – we really are very stupid at times.

… or easily distracted by surfaces.


Kat Arney’s new book, Herding Hemingway’s Cats: Understanding How Our Genes Work, is a gorgeously written, surprisingly gripping introduction to everything we’ve learned about genes since the famous Human Genome Project of several years ago. She explains and muses, explores and doubts, and I was amazed at how much I was learning as I coasted on her liquid prose. Good writing is like good lighting: You can see more. (About her title: Ernest Hemingway supposedly lived in Key West with a gaggle of six-toed cats. Where’d they get that extra one?)

Some of you may want to know more how a single regulatory gene produces 30 or more different variations of skin tone. Kingsley’s team discovered that Kitlg isn’t a simple on/off (or black/white) switch. That one teeny letter change made it harder for melanin production to be fully activated in Europeans, compared to Africans. Arney describes the details in this way:

A quick calculation in their paper suggests that having two copies of Kitlg with the European switch makes a person’s skin around six or seven shades lighter than someone with two West African versions. Because you have two copies of every gene – one from Mum and one from Dad – the effects of the switches will be more apparent if they are both the same, while having one of each will give a colour somewhere in the middle.

4 thoughts on “What Makes a Blond Blond? Very Little.

  1. Melanin does more than determine skin color. The Pineal gland is not mentioned at all. Blond is recessive and Black is Dominant

  2. Another wonderful post about a study that would make the world a far better place if it’s results were known by everyone

  3. It beggars the question of why people with only “one drop of black blood” is considered enough to make them “black” whereas it’s not a black thing at all. But then we all really knew that, didn’t we?

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